| I. | Technical Methods |
| immunophenotypic studies of hematopoietic and lymphoid neoplasms | |
| basic molecular and cytogenetic analysis of hematopoietic and lymphoid neoplasms | |
| flow cytometric testing for PNH | |
| principles of cytogenetic FISH studies | |
| blood smear review, bone marrow aspirate/biopsy review, body fluids | |
| General knowledge of
methods and method interferences PCR/RT-PCR FISH HPLC ELISA Spectrophotometric analysis TMAs | |
| II. | Hematopoiesis |
| Normal production, structure, and function | |
| III. | Erythrocytic Disorders |
| Thalassemia heterogeneity and lab diagnosis | |
| Sickle cell disease- lab diagnosis; role of lab in crisis management | |
| Evaluation of anemia | |
| IV. | Leukocyte Disorders |
| WHO (2001)
classification of hematopoietic and lymphoid neoplasms Broad general knowledge of disease states and associations, i.e. |
|
prognostication of CLL Zap 70 in CLL JAK2 and chronic myeloproliferative disorders FLT-3 in AML cutaneous lymphomas minimal residual disease monitoring therapy resistance - Gleevac new antibodies used to diagnose Hodgkin lymphoma continuing evolution and reliance on cytogenetic and flow cytometry to classify leukemias and lymphomas; limitations of morphology diagnosis and prognostic indicators for hematolymphoid lesions common cytogenetic abnormalities and their associations application and interpretation of routine/common flow cytometry markers serum and urine free light chains and monoclonal gammopathies |
| V. | Platelets |
| See MOC Content for Hemostasis and Coagulation | |
| VI. | Disorders of Coagulation & Hemostasis- |
| See MOC Content for Hemostasis and Coagulation | |
| VII. | Administration and Management- |
| See MOC Content for Lab Administration and Operations | |
| References |